Natureza Research Submitted for Publication in a Peer-Reviewed Journal Sep 2 2022
Natureza Research Submitted for Publication in a Peer-Reviewed Journal Sep 2 2022

Natureza Patents New Antibiotic Agents

Natureza Patents New Antibiotic Agents

  • Chitosan-coated carboxylic acids show antimicrobial activity against antibiotic-resistant Gram-negative and positive pathogens.
  • Our novel antibiotic agents show activity against some of the deadliest multi-drug resistant pathogens and there’s NO RESISTANCE.

Antibiotic resistance in bacteria is suggested to be the greatest risk to human health, but new agents are not being brought to market as the rapid evolution of resistance to them means that drug development costs cannot be recouped. Fatty acids have been proposed as a new generation of antibiotics, but toxicity and poor absorption has meant that their use has been impractical in the past. Chitosan has been used widely to coat other agents as nanoparticles, but has not been used with fatty acids.

We have shown that chitosan can be modified to direct fatty acids towards Gram-positive or negative bacteria so that they exert antimicrobial effects and that fatty acids work as effective antibiotics in vitro and in vivo, with activity against extremely drug resistant pathogens. Bacteria exposed to them do not develop resistance to these agents, and they are not toxic to mammalian cells. Activity was seen against salmonellosis and C. difficile infection in animal models.

Our results demonstrate that fatty acids formulated as chitosan nanoparticles are effective antibiotics, and can be used for a long period of time without resistance developing. This suggests that the usage of fatty acids coated in this manner could be sold in sufficient quantities to recoup its development costs, overcoming this barrier. These agents would form a new class of antibiotics, with the novel property of lack of bacterial resistance.

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Natureza Develops a Transformative New Class of Antibiotics that Overcomes Bacterial Resistance

Natureza’s patented formulations introduce a transformative new class of antibiotic agents that overcome bacterial resistance and removes the time barrier of investment return.

Natureza’s research offers a true paradigm shift, one that would remove the imbalance in development cost by eliminating the ability of bacteria to become resistant. With the promise of new drugs being able to be marketed for years providing not only the time to recover investment, but a profit as well, a new investment environment would emerge that would encourage the development of new, much needed antibiotics.

This work is protected by several US and foreign patents and patent applications.

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Lack of New Antibiotics Threatens Global Efforts to Contain Drug-Resistant Fnfections - WHO 2020

Lack of New Antibiotics Threatens Global Efforts to Contain Drug-Resistant Infections

“Never has the threat of antimicrobial resistance been more immediate and the need for solutions more urgent,” says Dr Tedros Adhanom Ghebreyesus, Director-General of WHO.

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2022-09-22T16:40:36+00:00
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