Antibiotic resistance in bacteria is acknowledged to be one of the greatest risks to human health. Unfortunately, new antibiotic agents are not being brought to market due in part to a rapid evolution of bacterial resistance to new and existing antibiotics.
Fatty acids as viable antibiotic agents have been proposed in the past but toxicity at high doses and poor absorption made them impractical for use. Natureza® has solved this problem by using the coating material Chitosan, a natural sugar, to coat the fatty acids and direct them towards Gram-positive or Gram-negative bacteria.
We have successfully shown these coated Fatty Acids work as effective antibiotics in in vitro and in vivo, with activity against some of the most drug resistant pathogens. Uniquely, bacteria exposed to them do not develop resistance.
Natureza’s work identifies a transformative new class of antibiotics with the novel property of lack of bacterial resistance. This work has been submitted for publication in a peer-reviewed journal and is protected by at least one US patent as well as several patent applications.